SortOrientation
type SortOrientation = xlSortColumns | xlSortRows
Description
Specifies if the sort should be by row or column.
Try It
oWorksheet.GetRange("A1:C5").SetSort("A1:A5", "xlAscending", "B1:B5", "xlDescending", "C1:C5", "xlAscending", "xlYes", "xlSortColumns");